To evaluate the safety, pharmacokinetics and efficacy of macaque-sized CLIP 3D printed intravaginal rings (IVRs) loaded with the potent antiretroviral Islatravir (EFdA) when administered vaginally to pigtailed macaques.

To support the introduction of a change in Burkina Faso’s infant pneumococcal vaccine schedule to include a booster dose and to evaluate the impact of the country’s capacity to control pneumococcal disease among children and adults.

To support implementation of a set of recommendations and a roadmap developed in the "Strengthening Public Health and Community Based Organization (CBO)" Interface report.

To evaluate the impact of a pneumococcal conjugate vaccine schedule change in Mozambique on vaccine-type pneumococcal carriage and invasive pneumococcal disease; and serotype 1 colonization among patients with suspected pneumonia and serotype 1 disease among children and adults.

To improve use of antibiotics in outpatient settings, where most prescribing occurs, by providing antibiotic stewardship resources for state health departments and state Medicaid agencies.

To provide laboratory support for the analysis of immunogenicity and shedding of new oral Poliovirus vaccines in human clinical trials and related issues for polio endgame.

To support efforts to strengthen and expand existing infection prevention control activities in various countries across Sub-Saharan Africa.

To evaluate the efficacy of injectable pre-exposure prophylaxis (PrEP) in HIV-uninfected populations.

To investigate other novel interventions, such as monoclonal antibodies (MAbs) against malaria. An intervention that could prevent malaria in children for a full 12 months in settings of perennial malaria transmission, such as Kenya, holds potential to reduce malaria morbidity and mortality substantially in this population at risk for severe malaria and death.

To support the chemistry, manufacturing and control (CMC) and preclinical development of an inactivated rotavirus vaccine.

To increase public awareness of water, sanitation and hygiene (WASH) issues and improve conditions in communities experiencing limited access or unsafe water systems in the United States.

To continue to increase health security in countries by improving their capacity and expanding support using new and more relevant tools of the National Action Plan for Health Security (NAPHS) Toolkit in at least six countries.

To maintain, produce, authenticate and distribute arthropod vectors and associated reagents for the Emerging Infections Resources Program.

To provide support to CDC, working toward the elimination of healthcare-associated infections in all medical care settings.

To build community resilience against weather events by supporting local disaster preparedness programs through community-based organizations in the Midwest, with a focus on rural areas.