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Investigating Safety and Efficacy of L9LS Monoclonal Antibodies in Western Kenya

1164
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infectious disease
Investigating Safety and Efficacy of L9LS Monoclonal Antibodies in Western Kenya
Kenya
To investigate other novel interventions, such as monoclonal antibodies (MAbs) against malaria. An intervention that could prevent malaria in children for a full 12 months in settings of perennial malaria transmission, such as Kenya, holds potential to reduce malaria morbidity and mortality substantially in this population at risk for severe malaria and death.
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Improving Water, Sanitation & Hygiene Services in Healthcare Facilities

The CDC Foundation is collaborating with the Centers for Disease Control and Prevention (CDC) to expand best practices for water, sanitation and hygiene (WASH) in healthcare facilities (HCFs) through implementation of targeted action research pilots in Uganda. These pilots involve developing and testing context-appropriate solutions for increasing uptake of WASH practices and sustained management of WASH services that meet the needs of patients and healthcare workers. Proposed action pilots will adapt promising interventions implemented in the United States and other healthcare settings to the context of Ugandan primary HCFs or identify new approaches where no interventions exist.

Pilot activities will include:

  • Identifying the determinants of sustainability of WASH infrastructure in HCFs through review of policies and practices among HCFs with well and poorly managed infrastructure;
  • Understanding patient and healthcare worker needs for drinking water and sanitation services, which remain understudied, and testing systems that meet their needs;
  • Assessing the effectiveness and acceptability of formalizing management responsibilities of WASH infrastructure that is often neglected, such as water supply and sanitation facilities, through standard operating procedures and job aids;
  • Identifying and testing culturally appropriate accountability systems for improving healthcare worker hand hygiene practices, including novel approaches that are suitable for small facilities.

There has been increased global focus in the past decade on the inadequate status of systems and WASH practices in HCFs and the importance of these systems for preserving the health and dignity of healthcare workers, patients and communities. Recent Ebola outbreaks and the COVID-19 pandemic have further highlighted the essential role of strong WASH systems in HCFs for infection prevention and control (IPC). However, despite advocacy and intervention efforts, global WASH in HCF stakeholder meetings in 2016 and 2019 continued to find significant gaps in sector knowledge. These include the need to identify effective approaches for sustainably managing WASH services and ensuring appropriate WASH practices are consistently adopted, particularly in aspects of patient and staff WASH needs that lie outside of IPC such as drinking water and sanitation.

As an increasing number of partners engage in WASH in HCF initiatives, evidence-based, field-tested best practices in these areas are needed to enable effective implementation and management by HCF leadership and supporting partners.

1162
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infectious disease
Improving Water, Sanitation & Hygiene Services in Healthcare Facilities
Uganda
To expand CDC’s strategic engagement in learning and evaluation of best practices for water, sanitation and hygiene (WASH) in health care facilities through implementation of targeted action research pilots in Uganda.
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Rotavirus Vaccine Impact and Effectiveness Assessments

1159
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infectious disease
Rotavirus Vaccine Impact and Effectiveness Assessments
Burkina Faso
Democratic Republic of the Congo
To ensure impact and effectiveness of rotavirus vaccines and sustain vaccine use by policy makers, physicians and parents to increase the speed of adoption of vaccine by other countries in Africa and around the world.
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Technical Assistance for Pneumococcal Carriage Study in Burkina Faso

1150
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infectious disease
Technical Assistance for Pneumococcal Carriage Study in Burkina Faso
Burkina Faso
To assess the impact of the Pneumococcal conjugate vaccine catch up campaign among internally displaced populations in the northern Sahel region of Burkina Faso. This effort will implement and evaluate the impact of changing the pneumococcal conjugate vaccine schedule.
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Characterization of Non-Rotavirus Viral Diarrheal Pathogens

1146
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infectious disease
Characterization of Non-Rotavirus Viral Diarrheal Pathogens
United States of America
To support the characterization of non-rotavirus viral diarrheal pathogens to inform the body of work that contributes to optimize the efficacy of rotavirus vaccines.
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Rotavirus Vaccine Effectiveness and Safety in Nigeria and Indonesia

1144
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infectious disease
Rotavirus Vaccine Effectiveness and Safety in Nigeria and Indonesia
Indonesia
Nigeria
To strengthen sentinel rotavirus surveillance in Nigeria and Indonesia and enable monitoring of trends in rotavirus hospitalizations pre- and post-vaccine introduction in order to observe the impact of rotavirus vaccines and serve as a platform for case-control evaluations of rotavirus vaccine effectiveness.
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Origin of Innate Immunity Suppression

1140
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infectious disease
Origin of Innate Immunity Suppression
United States of America
To further research how viral ovarian tumor protease activity is critical for replication and host tropism of nairoviruses.
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HIV Prevention Trials Network

1128
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Red Ribbon
HIV Prevention Trials Network
Thailand
To evaluate the efficacy of injectable pre-exposure prophylaxis (PrEP) for HIV-uninfected cisgender men and transgender women who have sex with men.
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Mechanisms of Norovirus Protective Immunity

1121
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infectious disease
Mechanisms of Norovirus Protective Immunity
United States of America
To screen a subset of human and mouse monoclonal antibodies for their ability to neutralize GI.1; a time ordered panel of GII.4; and GII.3 noroviruses using a novel human intestinal enteroid cell culture system.
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